The story takes place in Korat. Rosarin (Preem Ranida Techasit) lives alone with Rattana (Fresh Arisara Wongchalee), her mother. Rattana works tirelessly, finding products to sell to housewives and various shops because she wants to send Rosarin to the best school in the province. Rattana always teaches Rosarin that for a woman to survive, she must be decisive and stand on her own feet without relying on men. She also teaches Rosarin to be honest and not take advantage of customers. Rosarin thus becomes a tough young woman with her own thoughts, not liking to socialize with anyone. Rosarin doesn't want to be a direct salesperson like her mother because she dreams of being a musician in a marching band, which Rattana doesn't support. Rosarin thinks her mother doesn't care about her dreams, so she often quarrels with her mother until she can't stand it and thinks of running away to face the world alone. Only Chun (Masu Junyangdikul), a close male friend whom Rosarin trusts the most, encourages her. Chun secretly likes Rosarin but doesn't dare to flirt because he is a shy boy. Rosarin is very close to Chun because Chun always helps with homework, is a follower, and is willing to be an emotional outlet when Rosarin is unhappy. He is the only one who knows Rosarin's habits best. Hia Chai (Sumet Ong), Chun's father, owns a large construction material shop. Hia Chai is a kind widower who always helps buy Rattana's products and always helps Rattana. One day, Rosarin goes to pray to Ya Mo (Thao Suranari) for Rattana to allow her to compete in the marching band she passed the audition for. That day, the young girl meets Intu-on (Prim Prima Bhunjaroeun) and Anchita (Pattida Wagenschonner), two sisters who just moved from Bangkok to live with relatives in Korat. Intu-on has a personality opposite to Rosarin in every way; she is weak, fearful, soft-hearted, and doesn't fight back. Because Intu-on comes from a wealthy civil servant family, but both her parents died suddenly in an accident, Intu-on and Anchita, the two sisters, have to move in with their aunt who applied to be the administrator of the estate. Intu-on and Anchita's living conditions gradually change to become dependents because Urai, the aunt, takes money from the inheritance to support her own family instead and reduces various expenses of Intu-on and Anchita. Intu-on and Anchita are often bullied by new friends. Often, Rosarin has to step in to help reluctantly. Anchita is amazed by Rosarin's fearlessness and tries to follow her until Rosarin gets annoyed. One day, Intu-on is molested by her uncle-in-law. Rosarin steps in to help in time but runs back home, leaving the two sisters behind. The pair doesn't know what to do next, so they run away from home. Coincidentally, Rosarin also runs away from Rattana because she is angry that her mother didn't let her go to the music competition. Then fate brings the 3 of them together in a time of crisis because Intu-on and Anchita are about to be lured and abducted by criminals. Rosarin comes to help again. While things are bad, Hia Chai and Chun come to help in time. Hia Chai takes everyone to Rattana's house. Just then, Urai brings the police to arrest Rosarin for assaulting her husband. But Anchita tells her sister, who keeps crying, to tell the truth to everyone that she was molested by her uncle-in-law. Finally, Urai has to agree to go back but asks to leave her nieces at Rattana's house for 1 night. But the next morning, Rattana takes the children back, only to find that Urai and her husband have moved everything and fled. Rattana agrees to let the two girls stay with them, on the condition that both of them must help work to earn money for food and living. The two girls are very happy, but Rosarin is bored. Intu-on and Anchita become members of Rosarin's family. Time passes, Rosarin opens her heart and becomes best friends with Intu-on. As for Anchita, she sees Rosarin as an idol and imitates Rosarin in everything. Rosarin intends to study as high as possible to get a good job respected by general people so she doesn't have to be a salesperson like her mother. But then hope is extinguished when her mother has an accident and has to be in the ICU. Before her mother traveled, she even quarreled and cut ties with her mother because she caught her mother having a relationship with Hia Chai and was also angry with Chun for knowing everything but not telling her. Rosarin is sad, and the truth about her father that her mother never told, including the truth that her mother worked hard for her, gradually reveals itself. She is even more sad. Rosarin intends to fight and intends to be the family pillar instead of her mother, deciding to stop studying and let Intu-on and Anchita study. Rosarin takes over Rattana's direct sales work fully. Hia Chai asks to help by volunteering to take everyone to live at his house when Rattana gets out of the hospital so that he can help take care of Rattana. But then misfortune strikes again when a gas explosion causes a fire at Hia Chai's material warehouse. Hia Chai is burned to death. As for Chun, although his body is not found, the police assume that his body was shattered by the explosion. Rosarin is almost crazy with grief but has to try to stand up. Rattana's salesmanship helps Rosarin have a stable customer base. Intu-on and Anchita promise never to leave Rosarin and will help build their lives together. Rosarin intends to launch a new cream because she got a great formula. But then it seems fate brings Thanakorn (Mac Weerakaniz Kanwatthanakul), a cunning young man who used to charm girls and is being chased by the mafia for debt, to meet the 3 girls again. Then Thanakorn knows that Intu-on has assets, so he devises a plan to help Intu-on reclaim the ownership of the land and a sum of money of her parents back from Aunt Urai. Intu-on intends to use the money to invest in selling cream with Rosarin as they dreamed. But Thanakorn is afraid of starving for money, so he tricks Intu-on. Intu-on believes in the love Thanakorn tells her. The friendship reaches a breaking point when Intu-on runs away with Thanakorn and also steals the cosmetic formula. The revenge of the best friend begins. Time passes, Rosarin becomes a famous female executive in Korat. Rosarin meets a young man, Chanon (Masu Junyangdikul), whom she feels familiar with and who makes her heart flutter. But he has a background she doesn't know. On Anchita's side, after leaving Rosarin's house, she cut ties with her sister and changed her new name to Plaifah (Kate Marilyn Kate Gardner). After graduating, she comes back to apply for a job at Rosarin's company. The woman who is still waiting for revenge against those who betrayed her like Intu-on and Thanakorn. How will their lives be? Follow and watch in the drama "Twisted Destinies" airing every Friday - Sunday at 20.25 on Channel 3, press 33. Drama Twisted Destinies starts the first episode on Friday, April 25, 2025.